N-Iminopyridinium Ylide Compounds for SMARCA Protein Degradation

2026 research by Shijie Zhang introduces N-iminopyridinium ylides as chemically stable pharmacophores for targeted protein degradation. The dataset contains synthesized tetracyclic compounds, lead compound 4p, and PROTAC 14, with data on their binding, stability, and efficacy in cancer cell models. It is a 1.3 MB CSV file from figshare, last updated in March 2026.

Use Cases

• Predict compound stability in aqueous buffer and cell culture media from chemical structure features.
• Model the relationship between ylide moiety presence and degradation activity against SMARCA proteins.
• Analyze the pharmacokinetic properties of PROTAC 14 in rodent models from experimental data.
• Compare the binding potency of lead compound 4p to SMARCA2/4 bromodomains against its amide analog.

Strengths

• Includes experimental data for a novel, chemically stable pharmacophore class validated in cell and animal models.
• Provides head-to-head comparison data between the ylide scaffold and its corresponding amide analog.

Limitations

• Small dataset at 1.3 MB, indicating limited number of compounds or data points.
• Unknown row count and specific column schema limit assessment of data volume and feature diversity.
• Data is specific to SMARCA protein family and xenograft models, limiting generalizability to other targets.

Provenance

Source

figshare, authored by Shijie Zhang.

Collection Method

Experimental data from chemical synthesis, in vitro assays, cell culture studies, and in vivo xenograft models.

Time Range

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Freshness

Last updated March 2026.

Geography

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