N-Iminopyridinium Ylide Compounds for SMARCA Protein Degradation

Shijie Zhang's research dataset contains synthesized tetracyclic N-iminopyridinium ylide compounds for targeted protein degradation. The 20.7 MB XLSX file details chemical structures, stability data, and biological activity against SMARCA proteins. The dataset was last updated on March 26, 2026.

Use Cases

• Analyze binding potency to SMARCA2 and SMARCA4 bromodomains for lead compound 4p.
• Compare stability metrics of ylide compounds in aqueous buffer and cell culture media against amide analogs.
• Evaluate cell proliferation suppression and antitumor efficacy data from xenograft models for PROTAC 14.
• Assess pharmacokinetic parameters like cell permeability and rodent pharmacokinetics for novel degraders.

Strengths

• Dataset includes experimental data on a novel, chemically stable N-iminopyridinium ylide scaffold.
• Contains head-to-head comparison data between ylide compounds and corresponding amide analogs.

Limitations

• Dataset size is 20.7 MB, indicating a limited scope of experimental compounds and results.
• Specific row count and column details are unknown, limiting assessment of data comprehensiveness.
• Data is focused on specific SMARCA proteins and a single chemical scaffold, limiting generalizability.

Provenance

Source

Shijie Zhang via figshare.

Collection Method

Data originates from laboratory synthesis, computational studies, and in vitro/in vivo biological assays.

Freshness

Last updated March 26, 2026.