Experimental Data on Baicalein-Colistin Combination Against Gram-Negative Pathogens

An Excel dataset containing experimental results on the potentiation of colistin by the natural molecule baicalein. The data likely includes measurements of bacterial labile iron pools, lipopolysaccharide modifications, and membrane destabilization effects. The dataset was authored by Hui-Hui Zhang and last updated on April 27, 2026.

Use Cases

• Analyzing the relationship between iron homeostasis and colistin susceptibility based on labile iron pool measurements.
• Modeling the inactivation of the PmrA/B two-component system based on data on ferrous and ferric iron levels.
• Investigating ferroptotic-like damage in bacteria based on measurements of reactive electrophilic species.
• Evaluating combination therapy efficacy against multidrug-resistant pathogens based on in vitro and in vivo results.

Strengths

• Data is shared under a permissive CC-BY-4.0 license.
• File size is 5.2 MB, indicating a detailed but manageable dataset.
• The description provides a specific biological mechanism linking iron shifts to colistin efficacy.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from laboratory studies.

Freshness

Last updated 2026-04-27 10:35:50; freshness should be verified.