Heterocyclic Trifluoroacetylation Reactions via Photocatalysis

This dataset details a photocatalytic strategy for synthesizing heteroaromatic trifluoromethyl ketones. The protocol demonstrates the key Minisci coupling reaction across more than 10 unique heterocyclic classes, including pyridines, pyrazines, and quinolines. The data is provided in an XLSX file and was authored by Kyra L. Samony.

Use Cases

• Analyze reaction outcomes across the more than 10 unique heterocyclic classes, such as pyridines and pyrazines, to identify substrate scope trends.
• Validate the photomediated Minisci coupling protocol by examining experimental parameters for specific heterocycles like pyridazines and pyrimidines.
• Compare deketalization results for high-value aromatics documented in the dataset to assess reaction efficiency.

Strengths

• Demonstrates the Minisci reaction across more than 10 unique heterocyclic classes.
• Focuses on a specific and high-value chemical transformation: the synthesis of heteroaromatic trifluoromethyl ketones.
• Data is structured in a tabular XLSX format for straightforward analysis.

Limitations

• The dataset is very small at 14.6 KB, indicating limited scope and likely a small number of data points or examples.
• Specific quantitative metrics like row count, column names, and sample data are unavailable, limiting analytical depth.
• The data describes a specific laboratory protocol, which may not be generalizable to other chemical systems without adaptation.

Provenance

Source

Kyra L. Samony via figshare.

Collection Method

Experimental data from a reported organic synthesis protocol.

Freshness

Last updated on 2026-03-24.