Neuraminidase-Inhibiting Antibody Responses to H1N1pdm and H5N1 Clades

Kong Yen Liew's 2026 figshare dataset contains text files analyzing neuraminidase-inhibiting (NAI) antibody cross-reactivity. The data likely includes NAI titers from convalescent sera of H1N1pdm-infected patients against H1N1pdm and H5N1 strains, including clades 2.3.4.4b and 2.3.2.1a. The study demonstrates how seasonal H1N1pdm infection can transiently boost cross-reactive antibodies against specific H5N1 clades.

Use Cases

• Modeling antigenic divergence between influenza clades based on neuraminidase-inhibiting antibody titers.
• Analyzing the durability of cross-reactive antibody responses based on longitudinal data up to 90 days post-infection.
• Investigating the impact of specific amino acid residues on antibody cross-reactivity based on residue substitution experiments.
• Comparing antibody responses elicited by H1N1pdm versus H3N2 infections against H5N1 strains.

Strengths

• Includes comparative data on antibody responses against three distinct influenza strains: A/Victoria/4897/2022, A/California/7/2009, and H5N1 clades.
• Provides longitudinal analysis showing antibody response waning by day 90 post-infection.
• Data supports findings with specific geometric mean titer (GMT) comparisons, such as GMT 171 vs. GMT 1159.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 2.4 MB, suggesting it contains summary or processed data rather than raw experimental measurements.

Provenance

Source

figshare, author Kong Yen Liew

Collection Method

Likely contains serological assay results from patient and animal model studies.

Time Range

Study period not specified; includes data for strains up to A/Texas/37/2024.

Freshness

Last updated 2026-04-17 08:20:03

Geography

Geographic coverage of virus strains includes Victoria, California, Texas, and Bangladesh.