Neuro-reparative potential of hyperbaric oxygen therapy in animal models of Alzheimer’s an

Aiswarya Radhakrishnan's 2026 systematic review and meta-analysis investigates the neuro-reparative potential of hyperbaric oxygen therapy (HBOT) in preclinical models of Alzheimer's and Parkinson's diseases. The analysis synthesizes data from 8 studies involving 308 animals, with 182 included in the quantitative meta-analysis. It reports standardized mean differences for outcomes like cognitive function, motor performance, and various biochemical markers.

Use Cases

• Assessing the efficacy of hyperbaric oxygen therapy on cognitive function based on reported standardized mean differences for escape latency.
• Evaluating the impact of HBOT on motor performance in Parkinson's models based on data for distance traveled.
• Analyzing changes in neuroinflammatory and oxidative stress markers post-treatment based on reported levels of TNF-α, IL 10, SOD, and MDA.
• Investigating the effect on mitochondrial biogenesis and apoptosis based on reported markers like SIRT1, PGC-1α, and Bcl-xl.

Strengths

• Follows PRISMA and SYRCLE guidelines for systematic review and bias assessment.
• Includes quantitative meta-analysis of 182 animals from 8 identified studies.
• Reports specific standardized mean differences for key outcomes like escape latency (SMD: -2.13) and distance traveled (SMD: -6.94).

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is a 304.3 KB document, indicating a limited scope focused on review synthesis rather than raw experimental data.

Provenance

Source

Aiswarya Radhakrishnan via figshare.

Collection Method

Systematic review and meta-analysis conducted per PRISMA guidelines, using random-effect models.

Time Range

Covers studies identified through the review's search strategy; specific publication years of included studies are not provided.

Freshness

Last updated 2026-04-30 08:29:21; freshness should be verified.

Geography

Spatial coverage is not specified.