Neuronal Deformation and Morphology Data from High-Speed Interferometric Imaging

Six cells' neuronal deformation data recorded at 10 kHz sampling rate via quantitative phase microscopy, paired with confocal microscopy morphology images. The dataset supports the paper 'High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential' by Tong Ling. It provides a framework for studying electro-mechanical coupling in electrically active cells.

Use Cases

• Modeling electro-mechanical coupling in neurons based on synchronized deformation and morphology data
• Simulating electrical and structural models of membrane deformations on the provided cellular morphology
• Validating optical path length change measurements from quantitative phase microscopy against confocal image stacks
• Studying the dynamics of cellular shape changes during action potentials using high-temporal-resolution data

Strengths

• Data from six different cells provides a basis for comparative analysis
• Neuronal deformations were recorded at a high 10 kHz sampling rate
• Paired quantitative phase microscopy and confocal microscopy data allows for cross-modal validation

Limitations

• Row count and dataset size are unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Last update date is unknown; freshness unverified

Provenance

Source

Tong Ling, associated with the paper 'High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential'

Collection Method

Experimental data collected via quantitative phase microscopy with spike-triggered averaging synchronized to optogenetic stimulation, and confocal microscopy for morphology