New Analogs of Compstatin Complement Inhibitors with Affinity Data

Stephanie A. Vogt published this dataset on figshare in May 2026. It contains data on new macrocyclic peptide analogs of the compstatin family, which are clinical complement inhibitors. The description reports a low-picomolar-affinity derivative (Cp60) with a dissociation constant (K_D) of 0.08 nM.

Use Cases

• Analyzing structure-activity relationships based on the described V3I modification.
• Modeling target affinity and pharmacokinetic/pharmacodynamic (PK/PD) properties based on reported K_D values.
• Supporting diagnostic application development based on the described ultralong target residence time.
• Validating computational models of complement inhibition using the reported cryogenic electron microscopy structural insights.

Strengths

• Includes data on a derivative (Cp60) with a reported low-picomolar dissociation constant of 0.08 nM.
• Describes a 30-fold affinity enhancement from a specific modification (V3I).
• Data is associated with structural validation via cryogenic electron microscopy at 2.88 Å resolution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 9.5 KB, indicating limited scope.

Provenance

Source

Stephanie A. Vogt via figshare.

Collection Method

Likely contains experimental results from structure-activity relationship studies.

Time Range

null

Freshness

Last updated 2026-05-01 08:04:21; freshness should be verified.

Geography

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