Compstatin Analogs: Structural Data for Low Picomolar Complement Inhibitors

A 2026 dataset from figshare by Stephanie A. Vogt contains structural data for novel compstatin-class macrocyclic peptides. The data includes Protein Data Bank (PDB) files, likely from cryogenic electron microscopy, detailing the structure of a high-affinity derivative (Cp60) with a dissociation constant of 0.08 nM. The dataset is 507.3 KB in size and is licensed under CC-BY-NC-4.0.

Use Cases

• Analyzing the structural basis for enhanced target affinity based on the cryo-EM structure of the C3bB-Cp60 complex.
• Computational modeling of peptide-protein interactions based on the described V3I modification and its 30-fold affinity enhancement.
• Screening for diagnostic applications based on the described ultralong target residence time of the Cp60 derivative.

Strengths

• Includes structural data from cryogenic electron microscopy at 2.88 Å resolution.
• Documents a specific, highly potent derivative (Cp60) with a dissociation constant of 0.08 nM.
• Dataset has a clear, restrictive license (CC-BY-NC-4.0) and a named author.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (507.3 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Likely derived from experimental structure-activity relationship studies and cryogenic electron microscopy.

Time Range

2026

Freshness

Last updated 2026-05-01 08:04:18; freshness should be verified.

Geography

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