New Analogs of Compstatin Complement Inhibitors: Structural and Affinity Data

Stephanie A. Vogt published structural data for novel compstatin-class macrocyclic peptides on figshare in May 2026. The dataset includes a cryogenic electron microscopy structure of the C3bB-Cp60 complex at 2.88 Å resolution. It supports research into ultralong target residence times and low-picomolar affinity complement inhibitors.

Use Cases

• Analyzing the structural basis for enhanced target affinity based on the cryo-EM structure.
• Studying structure-activity relationships for peptide inhibitors based on the described V3I modification.
• Investigating diagnostic applications for detecting complement opsonins based on the described ultralong target residence time.
• Comparing proteinogenic and late-generation compstatin analogs based on the reported affinity values.

Strengths

• Includes a high-resolution cryo-EM structure at 2.88 Å.
• Reports specific affinity measurements, including a low-picomolar KD of 0.08 nM.
• Data is associated with a peer-reviewed research publication, suggesting methodological rigor.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (507.3 KB), indicating limited scope.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely generated from experimental structural biology and biophysical assays.

Time Range

Publication date suggests data is from research conducted prior to May 2026.

Freshness

Last updated 2026-05-01 08:04:17; freshness should be verified.

Geography

Organization is unknown; geographic coverage cannot be determined.