New Analogs of Compstatin: Structural Data for Low Picomolar Complement Inhibitors

Stephanie A. Vogt published structural data for novel compstatin-class macrocyclic peptides on figshare in May 2026. The dataset includes Protein Data Bank (PDB) files, likely containing atomic coordinates for peptide-protein complexes. This work highlights a modification (V3I) that enhanced target affinity up to 30-fold, yielding a derivative with a dissociation constant of 0.08 nM.

Use Cases

• Analyzing the structural basis for enhanced target affinity based on the cryo-EM structure of the C3bB-Cp60 complex mentioned in the description
• Modeling protein-peptide interactions for drug design based on the reported low-picomolar affinity derivatives
• Studying the impact of the V3I modification on binding kinetics based on the described 30-fold affinity enhancement
• Developing diagnostic applications for detecting complement opsonins based on the described ultralong target residence time

Strengths

• Includes high-resolution (2.88 Å) cryo-EM structural data for a key complex
• Reports specific, quantified binding affinities, such as a KD of 0.08 nM for the Cp60 derivative
• Data is shared under a clear, open license (CC-BY-NC-4.0)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (507.7 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Experimental research involving structure-activity relationship studies and cryogenic electron microscopy.

Time Range

Publication date is 2026; experimental timeframe is not specified.

Freshness

Last updated 2026-05-01 08:04:20; freshness should be verified

Geography

Geographic coverage is not specified.