NMN/SIRT2-Microtubule Axis Effects on Senescent Muscle Cell Mitochondria

A research dataset from figshare authored by Jie Cui, last updated in May 2026. It contains 10.7 MB of supporting documents analyzing the role of NMN and NAD+ in modulating SIRT2-related microtubule stability in senescent cells. The study demonstrates how NMN reactivates SIRT2 to restore microtubule dynamics and improve mitochondrial quality control.

Use Cases

• Study the link between microtubule hyper-stabilization and mitochondrial dysfunction based on the described SIRT2-tubulin axis.
• Investigate NMN's protective role in senescent cells based on the described mechanism beyond canonical NAD+-sirtuin pathways.
• Analyze the relationship between mtDNA leakage and CGAS-STING1 activation based on the described consequences of impaired mitophagy.
• Model the impact of tubulin acetylation on mitochondrial dynamics based on the described role of SIRT2 as a key deacetylase.

Strengths

• Dataset is licensed CC-BY-4.0, allowing for broad reuse.
• Description provides a detailed mechanistic hypothesis linking NMN, SIRT2, microtubules, and mitochondrial function.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 10.7 MB size suggests a small dataset, likely limited to supporting documents.

Provenance

Source

figshare

Collection Method

Likely contains experimental data and analysis from a biological study on senescent muscle cells.

Freshness

Last updated 2026-05-25 06:51:03; freshness should be verified.