CHG Index and MASLD in Type 2 Diabetes: Mediation Analysis of Inflammatory Markers

1,789 patients with type 2 diabetes aged 50 years or older were analyzed for the relationship between the CHG index and metabolic dysfunction-associated steatotic liver disease (MASLD). The study, authored by Binjing Pan and updated in April 2026, found a positive association mediated by immunoinflammatory markers like NAR, NLR, and SII. Diagnostic performance for MASLD was improved when combining the CHG index with SIRI, achieving an area under the ROC curve of 0.71.

Use Cases

• Modeling the nonlinear relationship between the CHG index and MASLD risk based on threshold analysis results.
• Investigating the mediating role of immunoinflammatory markers (NAR, NLR, SII) in metabolic disease pathways.
• Developing diagnostic classifiers for MASLD using combined indices like CHG and SIRI based on the ROC curve analysis.
• Comparing prevalence of MASLD across groups stratified by CHG index and inflammatory marker levels.

Strengths

• Includes data from 1,789 patients with type 2 diabetes, providing a substantive clinical sample.
• Analysis incorporates multiple advanced statistical methods: adjusted regression, threshold analysis, mediation analysis, and ROC curves.
• Examines six specific immunoinflammatory markers (CHG index, NAR, NLR, SII, SIRI, AISI) and their relationships with MASLD.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data is unknown, which may limit suitability assessment.
• The dataset is very small at 432.0 KB, indicating limited scope or that the uploaded file may only contain summary figures (PNG).

Provenance

Source

figshare, author Binjing Pan.

Collection Method

Clinical study dividing patients into MASLD and non-MASLD groups for comparative analysis.

Time Range

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Freshness

Last updated 2026-04-23 06:14:59; freshness should be verified.

Geography

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