Novel 3‑Methoxypropanamide Derivatives as Potential Antiseizure and Antinociceptive Agents

Marcin Jakubiec's dataset on figshare contains experimental results for novel 3-methoxypropanamide derivatives. The data includes in vitro and in vivo evaluations of antiseizure activity and antinociceptive effects across multiple models. The dataset was last updated on 2026-05-01.

Use Cases

• Modeling structure-activity relationships based on synthesized derivative properties.
• Analyzing dose-response efficacy based on reported ED50 values from seizure models.
• Evaluating drug-like properties based on pharmacokinetic and ADME-Tox study results.
• Investigating mechanistic pathways based on suggested dual mode of action involving 5-HT2C receptor agonism and sodium channel inhibition.

Strengths

• Data includes specific quantitative efficacy metrics, such as ED50 values of 35.6 mg/kg (MES) and 8.4 mg/kg (6 Hz, 32 mA).
• Experimental scope is broad, covering multiple seizure and pain models, including formalin-, capsaicin-, oxaliplatin-, and streptozotocin-induced models.
• Includes results from chronic treatment studies, such as suppression of seizure progression in the PTZ kindling model.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 8.0 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental data from designed, synthesized, and evaluated compounds.

Time Range

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Freshness

Last updated 2026-05-01 16:34:29; freshness should be verified.

Geography

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