Novel Carboline-Based Ferroptosis Inhibitor Ameliorates Acute Liver Injury by Remodeling P

Experimental data from the synthesis and screening of 53 carboline derivatives as ferroptosis inhibitors. The dataset likely contains results from phenotypic screening, including the EC50 value of 93 nM for the lead compound 4g in H9c2 cells, and its in vivo efficacy against acute liver injury models. The data was authored by Lijie Lv and last updated on April 30, 2026.

Use Cases

• Analyzing structure-activity relationships based on the 53 synthesized carboline derivatives.
• Modeling ferroptosis inhibitor efficacy based on EC50 values and phenotypic screening results.
• Investigating phosphatidylcholine remodeling mechanisms based on the CEPT1-dependent pathway described.
• Evaluating in vivo therapeutic potential for liver injury based on the ischemia-reperfusion, ConA-, and APAP-induced models mentioned.

Strengths

• Includes data on a specific, potent lead compound (4g) with a reported EC50 of 93 nM.
• Covers multiple in vivo acute liver injury models (hepatic ischemia-reperfusion, ConA-, and APAP-induced).
• Data is associated with a specific, recent update timestamp (2026-04-30 13:07:29).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (4.3 KB), indicating limited scope and likely a summary or key results table.

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory synthesis, phenotypic screening, and in vivo animal studies described in the associated research.

Time Range

null

Freshness

Last updated 2026-04-30 13:07:29; freshness should be verified.

Geography

null