BPN-37440: EP2 Antagonist Effects on Microgliosis and Memory in Epileptic Mice

Thota Ganesh published a dataset on figshare in April 2026. The data likely contains experimental results on the novel EP2 antagonist BPN-37440, measuring its effects on microgliosis and memory deficits in a pilocarpine-induced status epilepticus mouse model. The dataset is 5.0 KB in size.

Use Cases

• Modeling the relationship between EP2 antagonism and microgliosis attenuation based on regional brain measurements.
• Analyzing the correlation between anti-inflammatory action and memory deficit prevention in a mouse model.
• Validating in vitro ADME and in vivo PK properties of a novel compound against behavioral outcomes.

Strengths

• Data is associated with a specific, novel compound (BPN-37440) described in the study.
• Results include measurements from multiple brain regions (amygdala, cortex, hippocampus CA3).
• Dataset is published under a clear CC-BY-NC-4.0 license.

Limitations

• Dataset is very small at 5.0 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Thota Ganesh via figshare.

Collection Method

Likely contains experimental data from a laboratory study on mice.

Freshness

Last updated 2026-04-15 19:13:33; freshness should be verified.