MLL1 Morpheme 9-mers in Human Coding Sequences from GenBank

Human coding sequences from the GenBank database were analyzed for occurrences of MLL1 morphemes. The dataset is a text file listing 9-mers from human coding sequences, filtered to include only those with a CDS Rank greater than 2.00. It was created by Minou Bina of Purdue University West Lafayette to investigate constraints on synonymous codon utilization.

Use Cases

• Identifying sequence motifs with potential regulatory function based on their over-representation in coding sequences.
• Analyzing constraints on synonymous codon usage based on the presence of specific 9-mer morphemes.
• Training models to predict exon sequence context using 9-mer frequency data from genomic DNA versus coding sequences.

Strengths

• Data is derived from the authoritative GenBank database using the human genome build hg19.
• Includes a calculated 'CDS Rank' parameter to differentiate 9-mers of potential biological importance.
• Each record includes the 9-mer sequence, its frequency in total genomic DNA, its frequency in coding sequences, and its conceptual translation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Human coding sequences retrieved from GenBank.

Collection Method

9-mers were collected and analyzed from human coding sequences; frequencies were calculated against the total human genomic DNA (hg19).