OpenADMET-ExpansionRx Challenge: Blinded ADMET Data from RNA Drug Campaigns

Real-world ADMET data collected by Expansion Therapeutics during recent drug discovery campaigns for RNA-mediated diseases. The dataset contains measurements for off-targets and properties of interest, representing a blinded test set for the OpenADMET-ExpansionRx Challenge. It was published by openadmet on Hugging Face and last updated on October 27, 2025.

Use Cases

• Training models to predict ADMET properties based on real-world campaign data.
• Benchmarking ADMET prediction algorithms against blinded experimental results.
• Analyzing patterns in off-target effects mentioned in the description.
• Supporting the 'whack-a-mole' optimization process in preclinical drug discovery.

Strengths

• Contains real-world ADMET data from recently prosecuted drug discovery campaigns.
• Data originates from a specific series of campaigns by Expansion Therapeutics on RNA-mediated diseases.
• Last updated on October 27, 2025, indicating recent availability.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count, file formats, and sample data are unknown, which may limit suitability assessment.
• The dataset is blinded, which may restrict direct interpretation of the underlying molecular structures.

Provenance

Source

Expansion Therapeutics

Collection Method

Collected during optimization of candidate molecules for preclinical programs.

Time Range

From recent drug discovery campaigns (specific dates not provided).

Freshness

Last updated 2025-10-27 02:23:01

Geography

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