Cryo-EM Structure of NaV1.5 Channel in Complex with Azo-Q2a

A cryo-electron microscopy (cryo-EM) structure of the cardiac sodium channel NaV1.5 in complex with the photoswitchable blocker azo-Q2a. The dataset was authored by Zhuo Huang and uploaded to figshare on April 23, 2026. It contains a 3.1 Å resolution map stored in an MRC file format.

Use Cases

• Analyzing protein-ligand interactions based on the cryo-EM structure of NaV1.5 with azo-Q2a
• Validating computational docking models based on the high-resolution structural data
• Studying ion channel gating mechanisms based on the structural details of NaV1.5
• Designing novel photoswitchable drugs based on the binding site geometry revealed in the structure

Strengths

• High-resolution 3.1 Å cryo-EM structure provides detailed atomic-level information
• Dataset is openly available under a CC-BY-4.0 license for reuse

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Cryo-electron microscopy

Time Range

null

Freshness

Last updated 2026-04 23 07:04:34; freshness should be verified

Geography

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