optical screen based on pATM foci (Part I)

A 20.0 GB dataset from a screen of kinase inhibitors in HeLa cells treated with ionizing radiation (IR). The dataset uses the number of foci formed by S1981-phosphorylated ATM as a readout to identify kinases regulating ATM activation. It was authored by Chen Nie and last updated on 2026-04-27.

Use Cases

• Identify kinases regulating ATM activation downstream of IR treatment based on the pATM foci readout.
• Screen kinase inhibitors for their effect on DNA damage response signaling based on the foci quantification.
• Model the relationship between kinase inhibition and ATM phosphorylation foci formation based on the experimental results.

Strengths

• Large-scale dataset at 20.0 GB, suggesting substantial experimental data.
• Uses a specific, quantitative readout (S1981-phosphorylated ATM foci count) for analysis.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Comprehensive screen of kinase inhibitors in HeLa cells treated with ionizing radiation, using pATM foci as a readout.

Time Range

The experimental timeframe is not specified.

Freshness

Last updated 2026-04-27 12:09:03; freshness should be verified.

Geography

The geographic origin of the research is not specified.