optical screen based on pATM foci (Part II)

Chen Nie's dataset on figshare contains results from a comprehensive screen of kinase inhibitors in HeLa cells treated with ionizing radiation (IR). The data uses the number of foci formed by S1981-phosphorylated ATM as a readout to identify kinases regulating ATM activation. The dataset is 14.3 GB in size, was last updated on 2026-04-28, and is licensed under CC-BY-4.0.

Use Cases

• Identify kinase regulators of ATM activation based on the pATM foci count readout.
• Analyze the effect of specific kinase inhibitors on DNA damage response based on the screen results.
• Validate or compare kinase inhibitor libraries in the context of ionizing radiation treatment.

Strengths

• Dataset size is 14.3 GB, indicating a substantial volume of experimental data.
• Data is licensed under the permissive CC-BY-4.0 license, facilitating reuse.
• Last update date is 2026-04-28, suggesting recent maintenance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analyses.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Chen Nie via figshare.

Collection Method

Comprehensive screen of kinase inhibitors using HeLa cells treated with ionizing radiation (IR).

Time Range

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Freshness

Last updated 2026-04-28 01:28:03.

Geography

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