SHIP1 Ligand Optimization Data for Alzheimer's Disease Models

SHIP1 lipid phosphatase ligands were optimized and characterized for cellular target engagement in Alzheimer's disease models. The dataset, authored by Cynthia D. Jesudason and last updated in April 2026, contains results from biochemical, cellular, and lipidomic assays, including in vivo pharmacodynamic responses in an amyloidosis mouse model. The 538.6 KB XLSX file likely contains tabular data from these experimental studies.

Use Cases

• Analyzing structure-activity relationships (SAR) based on biochemical and cellular assay results mentioned in the description
• Modeling cellular target engagement based on thermal shift and protein-lipid overlay assay data
• Investigating phosphoinositide pool changes based on lipidomics results described
• Evaluating in vivo pharmacodynamic markers like gene expression and IL-1β levels in mouse models

Strengths

• Data includes results from multiple assay types (biochemical, cellular, lipidomic, in vivo) as described
• File is a structured XLSX format (538.6 KB), facilitating programmatic access
• Dataset has a specific CC-BY-NC-4.0 license, clarifying reuse terms

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Experimental research involving biochemical assays, cellular assays (THP-1 cells, microglia), and in vivo studies in mouse models.

Time Range

Experimental timeframe not specified; dataset last updated April 2026.

Freshness

Last updated 2026-04-30 12:06:16; freshness should be verified

Geography

Laboratory research; geographic scope not specified.