SHIP1 Ligand Optimization Data for Alzheimer's Disease Models

A 2.8 KB CSV file published by Cynthia D. Jesudason on figshare in April 2026. The dataset likely contains results from the optimization and characterization of a SHIP1 ligand, compound 32, for cellular target engagement and activity in Alzheimer's disease models. The description details biochemical assays, lipidomics, and in vivo pharmacodynamic responses in an amyloidosis mouse model.

Use Cases

• Analyzing structure-activity relationships (SAR) based on biochemical and cellular assay results mentioned in the description
• Modeling cellular target engagement based on thermal shift assay and lipidomics data described
• Evaluating in vivo pharmacodynamic markers based on gene expression and IL-1β level changes in a mouse model
• Studying microglial phagocytosis enhancement based on the uptake of myelin and amyloid debris described

Strengths

• Data is derived from multiple assay types described, including biochemical, cellular, thermal shift, and lipidomics
• Includes in vivo validation in an Alzheimer's disease mouse model as described
• Published under a CC-BY-NC-4.0 license, permitting non-commercial reuse with attribution

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small at 2.8 KB, indicating limited scope or a summary-level dataset

Provenance

Source

figshare

Collection Method

Likely contains experimental results from SAR studies, biochemical assays, and in vivo models as described.

Time Range

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Freshness

Last updated 2026-04-30 12:06:17; freshness should be verified

Geography

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