JS207: Optimization of Chelator Conjugation for Zr-89 ImmunoPET Imaging

Yang Jiang developed a Zr-89-labeled bispecific immuno-PET probe, JS207, for dual-target imaging of PD-1 and VEGF in tumors. The dataset likely contains parameters related to radiochemical purity (>99%), affinity constants (Kd = 6.92 nM for PD-1, 82.48 nM for VEGF-A), and pharmacokinetics (elimination half-life of 35.14 h). It was last updated on 2026-04-24.

Use Cases

• Optimizing chelator conjugation protocols based on radiochemical purity (>99%) and in vitro stability (>95% at 240 h)
• Evaluating bispecific antibody affinity based on reported dissociation constants (Kd) for PD-1 and VEGF-A
• Comparing pharmacokinetics of bispecific vs. monospecific probes based on elimination half-life and tumor retention data

Strengths

• High radiochemical purity (>99%) reported for the Zr-89-labeled probe
• Excellent in vitro stability (>95% at 240 h) documented
• Specific affinity constants provided (Kd = 6.92 nM for PD-1, 82.48 nM for VEGF-A)

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset size is 118.0 B, indicating a very limited scope

Provenance

Source

figshare

Freshness

Last updated 2026-04-24 05:14:01