Sildenafil Treatment Outcomes in British Men with Erectile Dysfunction

A prospective observational study of 147 men with erectile dysfunction (ED) presenting to a British district general hospital, assessing sildenafil (Viagra) therapy. The study recorded outcomes, adverse events, and patient acceptability, with follow-up reviews at 4, 12, and 52 weeks. Patients completed the International Index of Erectile Function (IIEF) questionnaire and provided data on willingness to pay for treatment.

Use Cases

• Analyze the correlation between patient-reported outcomes from the IIEF questionnaire and the 91% reported treatment success rate.
• Investigate the incidence of specific adverse events like headache, dyspepsia, flushing, and abnormal vision within the cohort.
• Model patient eligibility for NHS treatment based on clinical categories, distress criteria, and the presence of cardiovascular risk factors.
• Assess the relationship between patient willingness to pay (WTP) for treatment and their continuation rate with sildenafil therapy (80%).

Strengths

• Study includes a defined cohort of 147 men with longitudinal follow-up at 4, 12, and 52 weeks.
• Captures multiple outcome dimensions: efficacy (91% success), safety (adverse event profile), and patient perspectives (willingness to pay, NHS eligibility).
• Provides specific, quantified results for NHS treatment eligibility (30% under clinical categories, 18% under distress, 55% with cardiovascular risk factors).

Limitations

• Sample size of 147 patients is relatively small for broad statistical generalization.
• Data is from a single British district general hospital, which may limit geographic and healthcare system representativeness.
• Study period began in October 1999, so findings may not reflect contemporary treatment patterns or patient populations.

Provenance

Source

U.S. Department of Health & Human Services via Data.gov.

Collection Method

Prospective observational study.

Time Range

Patient enrollment began in October 1999, with follow-up through 52 weeks.

Freshness

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Geography

Patients presented to a British district general hospital.