Organelle Contact Reorganization and Calcium Signaling in Proteotoxic Stress

A research article investigating the molecular basis of cell-type specific responses to proteostatic stress. The study, authored by Yu B Ko and published on figshare in May 2026, examines how VCP/p97 inhibition triggers adaptive autophagy in endothelial cells versus cell death in colon cancer cells through organelle contact site reorganization and calcium signaling. The dataset consists of a 19.2 MB document in PDF and DOCX formats.

Use Cases

• Study the role of plasma membrane-ER-mitochondria contacts in cellular stress response based on the described experimental findings.
• Analyze calcium-dependent activation of AMPK and TFEB pathways in autophagy based on the described signaling mechanisms.
• Investigate cell fate determinants under proteotoxic stress based on the comparative analysis of HUVEC and HCT116 cell lines.
• Research the potential anti-cancer selectivity of VCP/p97 inhibition based on the described differential effects on endothelial versus cancer cells.

Strengths

• The underlying research is described in detail, providing context for the data.
• Files are available in two common document formats (PDF, DOCX).
• The dataset is licensed under CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• The dataset is a 19.2 MB document, not a structured data table; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• The description is a research abstract; metadata about specific experimental data files is limited.

Provenance

Source

figshare

Collection Method

Likely contains research data and analysis supporting the described study.

Freshness

Last updated 2026-05-19 05:33:38; freshness should be verified.