Crystallographic Data for Oxindole-Based Bridged Biaryl Compounds

A 2026 publication by Namrata Kotwal presents crystallographic information files (CIF) detailing the organocatalytic asymmetric synthesis of oxindole-based bridged biaryls. The dataset contains structural data for a class of molecules featuring three contiguous stereocenters and a chiral axis, synthesized via a cascade double aldol or double Henry reaction protocol under mild conditions.

Use Cases

• Analyze molecular structures and chiral axes from CIF files for oxindole-fused biaryl-bridged seven-membered carbocyclic scaffolds.
• Validate synthetic protocol efficiency by examining crystallographic data for products reported with high yields and enantioselectivities.
• Study the structural relevance of bridged biaryls featuring both central and axial chirality as documented in the CIF data.

Strengths

• Data originates from a peer-reviewed 2026 scientific publication, ensuring recent and documented provenance.
• Focuses on a specific, underexplored class of molecules (bridged biaryls) with documented high enantioselectivities.
• Provides crystallographic structure data (CIF format) for compounds with three contiguous stereocenters and a chiral axis.

Limitations

• Dataset is small (1.7 MB), likely containing structural data for only the synthesized compounds from the study.
• Limited to the specific chemical scope described (isatin derivatives with an ortho-formyl aryl substituent).
• No tabular data or quantified experimental results (e.g., yields, ee values) are provided in the described file format.

Provenance

Source

figshare, author Namrata Kotwal.

Collection Method

Experimental synthesis and crystallographic analysis documented in a research publication.

Time Range

Publication date 2026.

Freshness

Last updated March 2026.

Geography

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