Original Data Collection for Circ Paper PMC11483158: JAK-STAT Pathway Activation

Source data reported in the figures of a 2024 Circulation paper titled 'Sustained but Decoyed Activation of the JAK1-STAT Pathway by Aberrant Protein Aggregation Exacerbates Proteotoxicity.' The dataset was authored by Xuejun Wang and published on figshare in May 2026. It is a single XLSX file sized at 813.7 KB.

Use Cases

• Replicate statistical analyses from the published figures based on the underlying source data.
• Validate the reported findings on JAK-STAT pathway activation in response to protein aggregation.
• Conduct secondary analysis on the relationship between aberrant protein aggregation and proteotoxicity.
• Use as a reference dataset for modeling cellular signaling responses to proteotoxic stress.

Strengths

• Data is directly linked to a peer-reviewed publication in the journal Circulation (2024).
• Published under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.
• File size of 813.7 KB indicates a focused, manageable dataset.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Xuejun Wang.

Collection Method

Original data collection for the cited research publication.

Freshness

Last updated 2026-05-18 16:52:07; freshness should be verified.