Original Data for Fig. 5A-B: Hippocampal Synaptic Plasticity in PAC Knockout Mice

Junhua Yang published this dataset on figshare in 2026. It contains the original data underlying figures 5A and 5B from a study on synaptic plasticity. The data likely includes measurements of field excitatory postsynaptic potential (fEPSP) slopes from hippocampal brain slices of wild-type and PAC channel knockout mice.

Use Cases

• Replicate statistical analyses for the published figures based on the original fEPSP slope data.
• Compare long-term depression (LTD) and long-term potentiation (LTP) responses between genotypes based on the described electrophysiology experiments.
• Conduct secondary analysis on synaptic plasticity impairment linked to the PAC/TMEM206 channel.
• Validate computational models of NMDA receptor-dependent plasticity using the provided experimental data.

Strengths

• Data is directly linked to published research figures (Fig. 5A-B), providing traceability.
• The dataset is openly available under a CC-BY-4.0 license, permitting reuse with attribution.
• Files are provided in common, accessible formats (DOCX, XLSX).

Limitations

• The dataset is very small (114.4 KB), indicating limited scope and likely a focused subset of experimental results.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for some analyses.

Provenance

Source

figshare, author Junhua Yang.

Collection Method

Data was generated from electrophysiological recordings (fEPSP) on hippocampal brain slices from mice, following theta burst and low-frequency stimulation protocols.

Freshness

Last updated 2026-04-22 21:04:01; freshness should be verified.