Original 16S rRNA Sequencing Data for a Murine Model of Ulcerative Colitis and Depression

Original data of 16S rRNA sequencing from a study investigating the gut-brain axis in a murine model of ulcerative colitis and depression. The dataset, shared by Zhizhong Luo on figshare under CC-BY-4.0, includes results from behavioral tests, histopathology, ELISA, 16S rRNA sequencing, and non-targeted metabolomics. It was last updated on 2026-04-28.

Use Cases

• Analyzing gut microbiota dysbiosis based on 16S rRNA sequencing data mentioned in the description
• Investigating correlations between Bacteroides abundance and pro-inflammatory cytokine levels as described
• Studying glutathione depletion and ferroptosis pathway enrichment in colon and hippocampus tissue
• Modeling the activation of the hippocampal TLR4/NF-κB/NLRP3 pathway in relation to behavioral deficits

Strengths

• Dataset is openly shared under a CC-BY-4.0 license, facilitating reuse.
• Description details a multi-modal analysis including 16S rRNA sequencing and non-targeted metabolomics.
• The study design includes a defined murine model using DSS and CUMS protocols.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 14.2 KB, indicating limited scope.

Provenance

Source

Zhizhong Luo via figshare

Collection Method

Data generated from a laboratory study using a murine model with dextran sulfate sodium (DSS) and chronic unpredictable mild stress (CUMS), followed by 16S rRNA sequencing and metabolomics.

Freshness

Last updated 2026-04-28 06:42:04; freshness should be verified.