Murine Model Data on Gut-Brain Axis, Ferroptosis, and Depression in Ulcerative Colitis

A 573.2 KB dataset from a murine model study investigating the comorbidity of ulcerative colitis and depression. The data, shared by Zhizhong Luo on figshare under CC-BY-4.0, includes results from behavioral tests, histopathology, ELISA, 16S rRNA sequencing, and non-targeted metabolomics. It was last updated on April 28, 2026.

Use Cases

• Analyzing correlations between gut microbiota dysbiosis (e.g., Bacteroides abundance) and inflammatory markers based on 16S rRNA sequencing and ELISA data.
• Investigating ferroptosis pathway activation based on metabolomic markers like glutathione (GSH) depletion and elevated MDA.
• Modeling the relationship between hippocampal neuroinflammation and depressive-like behaviors based on behavioral test results and cytokine levels.
• Studying the TLR4/NF-κB/NLRP3 signaling pathway activation in the hippocampus in response to gut-derived stressors.

Strengths

• Includes multi-modal experimental data from behavioral tests, histopathology, ELISA, 16S rRNA sequencing, and non-targeted metabolomics.
• Dataset is openly shared under a permissive CC-BY-4.0 license, facilitating reuse.
• The study design explicitly links specific biological pathways (ferroptosis, TLR4/NF-κB/NLRP3) to behavioral outcomes.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a controlled murine model; direct applicability to human clinical contexts may be limited.

Provenance

Source

figshare, author Zhizhong Luo.

Collection Method

Data generated from a murine model using dextran sulfate sodium (DSS) and chronic unpredictable mild stress (CUMS), analyzed via behavioral tests, histopathology, ELISA, 16S rRNA sequencing, and non-targeted metabolomics.

Freshness

Last updated 2026-04-28 06:42:05; freshness should be verified.