Hippocampus Metabolic Profile from a Mouse Model of Ulcerative Colitis and Depression

A murine model study investigating the comorbidity of ulcerative colitis and depression. The dataset includes results from behavioral tests, histopathology, ELISA, 16S rRNA sequencing, and non-targeted metabolomics, generated by Zhizhong Luo and last updated on 2026-04-28. It is a 573.0 KB XLSX file shared under a CC-BY-4.0 license.

Use Cases

• Analyze correlations between gut microbiota dysbiosis (e.g., Bacteroides abundance) and pro-inflammatory cytokine levels based on 16S rRNA sequencing and ELISA data.
• Investigate markers of ferroptosis (e.g., GSH, MDA, GPX4) in the hippocampus and colon based on metabolomics and biochemical assay results.
• Model the relationship between hippocampal neurotransmitter levels (e.g., 5-HT, DA) and depressive-like behaviors (e.g., sucrose preference) based on behavioral and biochemical data.
• Study the activation of the TLR4/NF-κB/NLRP3 inflammatory pathway in the hippocampus in relation to systemic inflammation and intestinal barrier dysfunction.

Strengths

• Data is derived from a multi-modal experimental design including behavioral tests, histopathology, ELISA, 16S rRNA sequencing, and non-targeted metabolomics.
• The study investigates a specific mechanistic axis linking gut dysbiosis, ferroptosis, and neuroinflammation via the TLR4/NF-κB/NLRP3 pathway.
• Dataset is openly shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a controlled mouse model; direct applicability to human clinical contexts may be limited.

Provenance

Source

figshare, author Zhizhong Luo.

Collection Method

Data generated from a murine model using dextran sulfate sodium (DSS) and chronic unpredictable mild stress (CUMS).

Freshness

Last updated 2026-04-28 06:42:05; freshness should be verified.