Orthostatic stress testing in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

A study of 248 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and 22 healthy controls analyzed pressure pain thresholds and temporal summation before and after head-up tilt testing. The dataset includes results for patients with and without comorbid fibromyalgia, showing significant decreases in pain thresholds post-test. The research was authored by C Linda van Campen and published via the PapersWithCode platform.

Use Cases

• Compare pain sensitivity changes between patient groups and healthy controls based on pre- and post-head-up tilt test measurements.
• Investigate the relationship between comorbid fibromyalgia and pressure pain thresholds in ME/CFS patients.
• Analyze temporal summation ('windup') responses to orthostatic stress in a clinical cohort.
• Model the differential impact of orthostatic stress on finger versus shoulder pain perception.

Strengths

• Includes data from 248 ME/CFS patients and 22 healthy controls, providing a substantial clinical cohort.
• Reports specific, statistically significant results for pressure pain thresholds at finger and shoulder locations.
• Explicitly compares two patient subgroups: 164 with fibromyalgia and 84 without.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

PapersWithCode platform, author C Linda van Campen.

Collection Method

Clinical study involving orthostatic stress testing (head-up tilt test) and quantitative sensory testing.