NSUN3 and PCBP1 Gene Expression in Osteoarthritis Chondrocyte Ferroptosis

A 5.2 MB research dataset from figshare, last updated May 8, 2026, by author Wuluhan Mahan. It contains in vitro study data on RNA m5C modification's role in ferroptosis within osteoarthritis chondrocytes, including gene expression and protein level measurements from mouse models.

Use Cases

• Investigate the relationship between NSUN3 expression and ferroptosis markers based on malondialdehyde (MDA) and Fe2+ level data.
• Analyze m5C modification's impact on RNA stability based on methylated RNA immunoprecipitation (MeRIP) results described.
• Study gene regulatory mechanisms in osteoarthritis using differential expression analysis from the GSE129147 dataset mentioned.
• Model the effects of Interleukin-1β (IL-1β) stimulation on chondrocyte death based on protein level measurements for ACSL4, SLC7A11, and GPX4.

Strengths

• Dataset is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• The description provides specific methodological details, including the use of GSE129147 for differential gene expression and multiple assays (MeRIP, RIP, dual luciferase).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is derived from an in vitro mouse model; the description notes further in vivo validation is required.

Provenance

Source

figshare

Collection Method

Experimental data from in vitro mouse chondrocyte models treated with IL-1β, analyzed via assays including methylated RNA immunoprecipitation (MeRIP).

Freshness

Last updated 2026-05-08 13:10:36; freshness should be verified.