Oxadiazolone Derivatives: Antibacterial Activity and Target Profiling Against S. aureus

Oxadiazolone-core derivatives were investigated for their activity against planktonic, intracellular, and biofilm-associated Staphylococcus aureus. The dataset likely contains results for compounds like MpPPOX, iBPOX, and HPOX, including MIC values and target enzyme identification via activity-based protein profiling. Emma Forest published the data on figshare in May 2026 under a CC-BY-NC-4.0 license.

Use Cases

• Identify promising oxadiazolone compounds for drug development based on their bactericidal, intracellular, and antibiofilm activities.
• Analyze the relationship between compound structure and target enzymes, such as FabH, based on activity-based protein profiling results.
• Compare the efficacy of experimental compounds like MpPPOX against standard treatments like vancomycin using MIC data.
• Investigate multitarget inhibition strategies for broad-spectrum antimicrobials based on the covalent binding to (Ser/Cys)-based enzymes.

Strengths

• Data is derived from a structured scientific study investigating three distinct antibacterial activities (planktonic, intracellular, biofilm).
• The dataset includes identified target enzymes for specific compounds, such as FabH for MpPPOX.
• File is provided in the structured XLSX format, suitable for tabular analysis.

Limitations

• The dataset is very small at 39.9 KB, indicating limited scope and likely a focused experimental result set.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale statistical modeling.

Provenance

Source

Emma Forest via figshare.

Collection Method

Likely contains experimental results from antibacterial activity assays and activity-based protein profiling combined with mass spectrometry.

Freshness

Last updated 2026-05-04 20:43:34; freshness should be verified.