31 Immune-Key Genes Related to Psoriasis: Hub Genes and Immune Infiltration

A 17.0 KB dataset containing 31 immune-related key genes identified from multiple psoriasis patient microarray datasets. The data was generated by Yuzhen Sun using differential gene analysis, WGCNA, LASSO, and PPI network methods, and was last updated on 2026-04-20. It includes six validated hub genes (CLEC7A, CXCL1, IRF1, S100A12, S100A8, S100A9) with links to disease severity and treatment outcomes.

Use Cases

• Identifying potential therapeutic targets for psoriasis based on the six validated immune-related hub genes.
• Analyzing correlations between gene expression and psoriasis disease severity based on the described Pearson correlation analysis.
• Investigating immune cell infiltration in psoriatic lesions based on the CIBERSORT algorithm results mentioned in the description.
• Validating biomarker performance for psoriasis based on the described within-sample discrimination (AUC > 0.9) of hub genes.

Strengths

• Includes six validated hub genes (CLEC7A, CXCL1, IRF1, S100A12, S100A8, S100A9) with high discriminatory power (AUC > 0.9).
• Derived from analysis of five publicly available microarray datasets (GSE30999, GSE106992, GSE14905, GSE78097, GSE117468).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (17.0 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Analysis of multiple public microarray datasets using differential gene analysis, WGCNA, LASSO, and PPI network methods.

Time Range

Temporal coverage of the source microarray datasets is not specified.

Freshness

Last updated 2026-04-20 17:39:08; freshness should be verified.

Geography

Spatial coverage is not specified.