Differentially Expressed Genes in dnChREBP-Modified NCI-H1975 Cells

650 genes show significant expression changes in a lung cancer cell line engineered to overexpress a dominant-negative form of the ChREBP transcription factor. The dataset, shared by Athisake Ruangpracha on figshare, lists genes with an adjusted p-value < 0.05 and an absolute log2 fold-change greater than 2. It was last updated in April 2026 and is available as a 78.5 KB Excel file.

Use Cases

• Identify potential downstream targets of the ChREBP transcription factor based on significant expression changes.
• Analyze metabolic pathway alterations in cancer cells based on the list of upregulated and downregulated genes.
• Validate or compare gene expression signatures from other lung cancer studies using this focused gene list.
• Prioritize candidate genes for functional follow-up experiments in metabolic oncology research.

Strengths

• Includes 650 genes meeting stringent statistical thresholds (adjusted p-value < 0.05, |log2FC| > 2).
• Data is shared under a permissive CC-BY-4.0 license, allowing for broad reuse.
• File size is 78.5 KB, making it quick to download and inspect.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for some statistical methods.
• The dataset is specific to a single modified cell line (NCI-H1975), limiting generalizability.

Provenance

Source

figshare, author Athisake Ruangpracha.

Collection Method

Likely derived from RNA sequencing or microarray analysis of genetically modified NCI-H1975 cells.

Time Range

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Freshness

Last updated 2026-04-30 17:25:01; freshness should be verified.

Geography

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