AbSeq Antibodies: Single-Cell T Cell Data from Malaria-Exposed Organoids

AbSeq Antibodies is a dataset by Kathleen D. Press, last updated in April 2026. It contains single-cell RNA/TCR sequencing data from human tonsil and spleen organoids exposed to malaria parasites. The data likely includes measurements of Vδ2+ γδ T cell frequencies, clonal expansion, and cytotoxic phenotypes.

Use Cases

• Analyzing clonal expansion of Vδ2+ T cells based on TCR repertoire data mentioned in the description
• Modeling cytotoxic T cell phenotypes based on expression of granzymes and interferon-stimulated genes
• Comparing immune responses in malaria-naïve versus malaria-exposed lymphoid organoids
• Validating in vitro organoid findings against ex vivo tonsil samples from children with parasitemia

Strengths

• Data is derived from novel human tonsil and spleen organoid models
• Includes validation using ex vivo tonsil samples from Ugandan children
• Released under a permissive CC-BY-4.0 license

Limitations

• Dataset is very small at 5.5 KB, indicating limited scope
• Row count and column-level documentation are absent
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

Kathleen D. Press via figshare

Collection Method

Single-cell RNA/TCR sequencing of human lymphoid organoids exposed to Plasmodium falciparum-infected red blood cells

Time Range

null

Freshness

Last updated 2026-04-10 18:00:32; freshness should be verified

Geography

Organoid donors and Ugandan children samples mentioned