Anti-CS3 IgA Titres: Vaccine-Induced Antibody Avidity in Zambian Children

Zambian children aged 6–23 months (n=60) received three doses of the ETVAX® vaccine with dmLT adjuvant. The dataset contains plasma antibody avidity indices for CS3 and LTB antigens measured at baseline and after vaccinations. It was authored by Cynthia Mubanga and last updated on 2026-05-15.

Use Cases

• Compare antibody avidity and titre-based classifications of immune naivety.
• Analyze the relationship between natural exposure and vaccine-induced antibody quality.
• Evaluate the performance of avidity indices for discriminating immune maturity using ROC analysis.
• Study inter-individual variability in antibody responses to the ETVAX® vaccine.

Strengths

• Includes data from 60 pediatric participants.
• Measures antibody avidity at three time points (baseline, day 22, day 97).
• Applies two classification methods for immune naivety (titre-based and avidity-defined).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 9.9 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Plasma samples were analyzed by limiting antigen dilution ELISA to calculate avidity indices.

Time Range

Study involved vaccinations and sample collection over at least 97 days.

Freshness

Last updated 2026-05-15 17:25:32; freshness should be verified.

Geography

Zambia