MWAC-3475 Series: Anti-flavivirus Compound Screening Results

Novel benzamide compounds with EC50 values of 40–400 nM against Zika virus, discovered via phenotypic high-throughput screening. The dataset, published by Donghoon Chung in 2026, contains results confirming NS4B protein interference as the primary antiviral mechanism. These findings support the development of pan-flavivirus therapeutics.

Use Cases

• Training ML models for compound potency prediction based on EC50 and CC50 values.
• Analyzing structure-activity relationships for benzamide-based antiviral leads.
• Investigating viral resistance mechanisms based on NS4B protein mutation data.
• Comparing antiviral mechanisms of action against different flaviviruses like dengue and yellow fever.

Strengths

• Potency data includes specific EC50 values ranging from 40–400 nM.
• Mechanism of action is confirmed via time-of-addition assays and resistance mutation studies.
• Data is published under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

Donghoon Chung via figshare

Collection Method

Phenotypic, cytopathic effect-based high-throughput screening followed by medicinal chemistry optimization.

Time Range

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Freshness

Last updated 2026-04-03 18:00:30; freshness should be verified.

Geography

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