Anti-LTB IgG Titres: Vaccine-Induced Antibody Avidity in Zambian Children

60 children aged 6–23 months in Zambia received three quarter-doses of the ETVAX® vaccine with dmLT adjuvant. The dataset contains plasma sample analyses from baseline and post-vaccination time points, measuring anti-CS3 and anti-LTB IgG antibody avidity indices. Author Cynthia Mubanga published the data on figshare under a CC-BY-4.0 license, last updated in May 2026.

Use Cases

• Compare antibody avidity indices against titre-defined naïve status based on the described classification methods.
• Analyze the temporal changes in IgG avidity for CS3 and LTB antigens post-vaccination.
• Assess the discriminatory performance of avidity indices using ROC analysis metrics like AUC.
• Investigate the prevalence of functional naivety (low avidity despite detectable titres) in an endemic pediatric population.

Strengths

• Includes data from 60 pediatric participants, providing a defined cohort size.
• Contains longitudinal measurements from three specific time points: baseline (Day 1), post-second dose (Day 22), and post-third dose (Day 97).
• Explicitly reports key statistical results like mean avidity values and p-values, indicating analyzed data.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical needs.
• The dataset is very small at 11.7 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Plasma samples from a clinical trial were analyzed by limiting antigen dilution ELISA to calculate avidity indices.

Time Range

The study timeline includes measurements at Days 1, 22, and 97.

Freshness

Last updated 2026-05-15 17:25:31; freshness should be verified.

Geography

Data was collected from children in Zambia.