VEEV Infection Mouse Model Neuropathology and Transcriptomic Data

A 9.5 KB Excel file from a 2026 study by Morgen VanderGiessen on Venezuelan equine encephalitis virus (VEEV) infection in mice. It contains neuropathological, behavioral, and single-cell transcriptomic data from C57BL/6 mice infected intranasally with VEEV TC-83, tracked up to 106 days post-infection.

Use Cases

• Correlate persistent motor dysfunction and memory impairment scores with single-cell transcriptomic profiles of glial cell activation.
• Analyze longitudinal changes in inflammatory signaling gene expression from single-cell data across acute and chronic infection time points.
• Model neuron loss in the hippocampus against behavioral metrics like anxiety-like behavior observed up to 106 DPI.
• Investigate the relationship between acute neurological symptom severity and chronic alterations in synaptogenic signaling gene expression.

Strengths

• Longitudinal data tracks subjects up to 106 days post-infection, capturing chronic effects.
• Integrates multiple data modalities: neuropathology, behavior, and single-cell transcriptomics.
• Published under a permissive CC-BY-4.0 license on figshare in 2026.

Limitations

• Very small dataset at only 9.5 KB, indicating limited sample size or feature count.
• Data is specific to a single mouse strain (C57BL/6) and viral strain (VEEV TC-83), limiting generalizability.
• Column names and exact data structure are unknown, requiring inspection before analysis.

Provenance

Source

Study by author Morgen VanderGiessen, published on figshare.

Collection Method

Data gathered from longitudinal examination of C57BL/6 mice intranasally infected with VEEV TC-83.

Time Range

Study tracks outcomes from infection up to 106 days post-infection.

Freshness

Last updated in April 2026.