Hypoxia-Induced Nucleus Pulposus Cell Senescence Data

Qi Liang published this dataset on figshare in May 2026. It contains experimental data from a study investigating S-palmitoylation's role in nucleus pulposus cell senescence under hypoxic conditions, a model for intervertebral disc degeneration. The dataset is stored in an XLS file and is 5.5 KB in size.

Use Cases

• Analyze the relationship between IP3R S-palmitoylation levels and mitochondrial-associated membrane (MAM) abnormalities based on the described experimental model.
• Investigate the expression levels of apoptosis markers (e.g., Bax, Bcl-2, Cleaved-Caspase3) and matrix components (e.g., COL2, AGG) under hypoxic stress.
• Study the regulatory effect of the palmitoylation-modifying enzyme DHHC6 on proteins like GRP75, VDAC1, Drp1, and Mfn2.
• Model changes in intracellular calcium, ROS levels, and mitochondrial membrane potential in senescent cells.
• Correlate protein expression of matrix-degrading enzymes (MMP3, MMP13) with extracellular matrix protein expression in the context of cell senescence.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.
• File size is precisely known at 5.5 KB, indicating a focused and manageable dataset.
• The description provides a detailed biological context and specific molecular targets for the experimental data.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (5.5 KB), indicating limited scope and likely a supplementary result table rather than a primary research corpus.

Provenance

Source

figshare, author Qi Liang.

Collection Method

Likely contains experimental measurements from a constructed hypoxia-induced nucleus pulposus cell model.

Time Range

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Freshness

Last updated 2026-05-22 17:41:59; freshness should be verified.

Geography

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