Appendix I: Taurine Supplementation Trial Data for Metabolic Health

A dataset from a Bayesian-optimized phase II randomized controlled trial investigating the effects of a 6-month oral taurine supplementation program on healthcare workers. The trial, registered with the Chinese Clinical Trial registry (ChiCTR2500102879), enrolled up to 80 participants and measured outcomes including glycated hemoglobin (HbA1c), plasma lipids, blood pressure, and PhenoAge. The data was uploaded by Mandy H. M. Chu on figshare and last updated on 2026-05-27.

Use Cases

• Analyzing the effect of taurine on blood glucose control based on changes in glycated hemoglobin (HbA1c) levels.
• Evaluating secondary health outcomes based on changes in plasma lipid levels, blood pressure, and body weight.
• Studying trial design efficiency based on the described Bayesian-optimized stopping rules for futility or superiority.
• Assessing biological aging markers based on the PhenoAge and skin autofluorescence index measurements.

Strengths

• Data originates from a registered clinical trial (ChiCTR2500102879) with a defined protocol.
• The trial design includes Bayesian optimization and stratified randomization by diabetes status and age.
• Outcomes include multiple health parameters such as HbA1c, lipids, blood pressure, and PhenoAge.

Limitations

• The dataset is very small at 11.5 KB, indicating limited scope.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The description does not specify the final enrollment number or the trial's geographical scope.

Provenance

Source

figshare, uploaded by Mandy H. M. Chu.

Collection Method

Data collected from a 1:1 randomized controlled trial with Bayesian-optimized design.

Time Range

The trial protocol is dated 19 September 2025; the dataset was updated in 2026.

Freshness

Last updated 2026-05-27 17:30:15; freshness should be verified.