<p>Auto-CUT&Tag sequencing results of proliferating <i>Kat6a</i>^{<i>–/–</i>} vs.

Auto-CUT&Tag sequencing results from proliferating neural stem progenitor cells (NSPCs) comparing Kat6a knockout (Kat6a–/–) to wild-type (Kat6a+/+) genotypes. The dataset, authored by Anne K. Voss and last updated in May 2026, contains differential genomic region occupancy data for six histone modifications and proteins across multiple spreadsheet tabs. The file is 37.9 MB in size and is available under a CC-BY-4.0 license.

Use Cases

• Identify genomic regions with differential histone acetylation (H3K9ac, H3K14ac, H3K23ac) based on the described occupancy data.
• Analyze changes in H3K4 trimethylation (H3K4me3) and RNA polymerase II (POLR2A) binding in Kat6a-deficient cells.
• Investigate the co-occupancy or regulatory relationships between the histone methyltransferase MLL1 and other epigenetic marks.
• Compare the epigenetic landscape of wild-type versus Kat6a knockout neural stem progenitor cells (NSPCs).

Strengths

• Contains differential occupancy data for six distinct epigenetic marks and proteins (H3K9ac, H3K14ac, H3K23ac, H3K4me3, MLL1, POLR2A).
• Data is structured in a 37.9 MB XLSX file with results logically separated into tabs.
• Dataset has a clear, permissive license (CC-BY-4.0) for reuse and redistribution.
• Last update timestamp is precise (2026-05-04 17:43:55).

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality and statistical thresholds require manual inspection.

Provenance

Source

Anne K. Voss via figshare.

Collection Method

Auto-CUT&Tag sequencing performed on proliferating neural stem progenitor cells (NSPCs).

Time Range

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Freshness

Last updated 2026-05-04 17:43:55.

Geography

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