B Cell Panel: Single-Cell RNA/TCR Sequencing Data from Lymphoid Organoid Malaria Study

A 5.5 KB Excel dataset from a 2026 study by Kathleen D. Press on figshare. It contains data from human tonsil and spleen organoids exposed to malaria parasites, with analysis of Vδ2+ γδ T cell frequencies, clonal expansion, and cytotoxic phenotypes. The work includes validation using tonsils from Ugandan children with asymptomatic parasitemia.

Use Cases

• Analyzing clonal expansion of Vδ2+ T cells based on TCR repertoire data mentioned in the description
• Investigating cytotoxic phenotype differentiation based on expression of granzymes and interferon-stimulated genes
• Comparing immune responses in malaria-exposed versus malaria-naïve conditions using organoid model data
• Validating in vitro organoid findings with ex vivo data from human tonsil samples

Strengths

• Data is openly licensed under CC-BY-4.0
• Includes validation with human tissue samples from Ugandan children
• Study uses novel human tonsil and spleen organoid models

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Dataset is very small at 5.5 KB, indicating limited scope

Provenance

Source

figshare

Collection Method

Data generated from single-cell RNA/TCR sequencing of human lymphoid organoids and validation with human tonsil samples.

Time Range

Study published in 2026

Freshness

Last updated 2026-04-10 18:00:26; freshness should be verified

Geography

Organoid donors are malaria-naïve; validation samples are from Ugandan children.