PCI Trial Baseline Characteristics for Antiplatelet Therapy Meta-Analysis

Seven randomized trials with 27,743 patients, from inception through August 2025, are included in this meta-analysis. It provides baseline characteristics for studies comparing early aspirin withdrawal with P2Y12-inhibitor monotherapy versus continued dual antiplatelet therapy after percutaneous coronary intervention. The dataset was created by researcher Eliano P. Navarese and published in March 2026.

Use Cases

• Analyze trial-level baseline characteristics like patient count (n=27,743) and intervention types (immediate vs. early aspirin withdrawal) to assess study population homogeneity.
• Model the relationship between aspirin withdrawal timing and primary outcomes (myocardial infarction, clinically relevant bleeding) using reported hazard ratios and confidence intervals.
• Perform Bayesian analysis simulations using posterior probability data (e.g., 100% probability of bleeding benefit) for different patient risk profiles (high bleeding/ischemic risk).
• Validate trial sequential analysis (TSA) findings on evidence conclusiveness for bleeding benefit and myocardial infarction futility using aggregated trial data.
• Investigate subgroup results, such as the increased MI risk (HR=1.41) associated with immediate aspirin noninitiation/cessation versus early discontinuation.

Strengths

• Aggregates data from 7 randomized controlled trials, a standard for high-quality evidence synthesis.
• Includes a substantial patient population of 27,743 individuals for analysis.
• Reports precise statistical metrics, including hazard ratios, 95% confidence intervals, and Bayesian posterior probabilities.

Limitations

• Contains only aggregate, trial-level data, preventing patient-level or longitudinal analysis.
• Limited precision for specific subgroups, such as the immediate aspirin withdrawal analysis, due to smaller sample sizes.
• The 9.5 KB file size indicates a very small dataset, likely containing only summary tables without raw patient records.

Provenance

Source

Figshare, authored by Eliano P. Navarese.

Collection Method

Meta-analysis of randomized controlled trials identified from database inception through August 2025.

Time Range

Trials from inception through August 2025; analysis published in 2026.

Freshness

Last updated March 2026, with literature search through August 2025.