UK Biobank Participant Baseline Features for Frailty and Osteomyelitis Study

466,918 participant records from the UK Biobank, collected between 2006 and 2010, form the basis of this nested case-control study. The data links baseline frailty status, assessed via a five-item phenotype, with incident osteomyelitis cases identified through health records up to December 2022. Can Guo published this dataset under a CC-BY-4.0 license to support research on geriatric health outcomes.

Use Cases

• Train predictive models for osteomyelitis risk based on baseline frailty status and other clinical factors.
• Analyze dose-response relationships between frailty categories and adverse health outcomes.
• Conduct subgroup analyses to test the robustness of frailty associations across different patient demographics.
• Replicate conditional logistic regression analyses on matched case-control data.

Strengths

• Data originates from the large-scale UK Biobank cohort of 466,918 participants.
• Cases and controls are matched at a 1:5 ratio by age, sex, and assessment center.
• Frailty is assessed using a standardized five-item phenotype adapted from established Fried criteria.
• Study results show statistically significant odds ratios (e.g., OR=2.79 for frail individuals).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the specific analytic dataset is unknown, which may limit suitability assessment.
• The 9.5 KB file size suggests a very limited, likely summary-level dataset rather than the full cohort data.

Provenance

Source

UK Biobank

Collection Method

Nested case-control study using linked electronic health records.

Time Range

Baseline recruitment: 2006-2010; outcome follow-up up to 19 December 2022.

Freshness

Last updated 2026-06-01 17:49:02; freshness should be verified.

Geography

United Kingdom