Meta-Analysis of Dietary Inflammation and Liver Disease Risk

Encompassing extracted data from a systematic review and meta-analysis of 18 studies involving 262,468 participants. It examines the association between the Dietary Inflammatory Index (DII) and the incidence and progression of non-alcoholic fatty liver disease (NAFLD). The analysis includes odds ratios, confidence intervals, and results from sensitivity and subgroup analyses.

Use Cases

• Calculate pooled odds ratios for the association between DII and NAFLD risk using extracted effect sizes.
• Perform subgroup analysis to explore heterogeneity sources identified in the meta-analysis, such as geographic region and diagnostic criteria.
• Assess publication bias for NAFLD studies using statistical methods like Egger's test as described in the review.

Strengths

• Aggregates data from 18 studies with a total of 262,468 participants.
• Includes results from sensitivity and subgroup analyses to investigate heterogeneity.
• Provides specific odds ratios and confidence intervals for the DII-NAFLD and DII-fibrosis associations.

Limitations

• The dataset is small at 17.5 KB, indicating limited raw data or summary statistics only.
• The underlying studies may have geographic or diagnostic heterogeneity, as noted in the subgroup analysis.
• Publication bias was detected for NAFLD outcomes, which may affect the overall pooled estimates.

Provenance

Source

Systematic searches in PubMed, Web of Science, Embase, Scopus, and the Cochrane Library.

Collection Method

Random-effects meta-analysis performed with Review Manager 5.4 and STATA 15.0.

Time Range

Literature search covered studies up to July 2025.

Freshness

Literature search was conducted up to July 2025, with the dataset last updated in March 2026.

Geography

Geographic region was identified as a source of heterogeneity in subgroup analysis.