BCVA Long: 10-Year Visual Acuity Trajectories in Japanese LHON Patients

27 Japanese patients with Leber hereditary optic neuropathy (LHON) were followed for over 10 years, providing long-term visual acuity data. Best-corrected visual acuity (BCVA) was collected monthly from onset to 120 months, with piecewise linear models fitted over Acute, Chronic, and Late Chronic phases. The dataset, created by Yasuyuki Takai and shared under CC-BY-4.0, offers phase-specific benchmarks for a condition where long-term data is limited.

Use Cases

• Model long-term visual acuity trajectories based on piecewise linear phases described in the study.
• Estimate cumulative probabilities of achieving specific BCVA thresholds (e.g., ≤1.6 logMAR) over a decade.
• Analyze visual outcome differences between genetic subgroups, such as the m.11778G>A variant mentioned.
• Benchmark natural history of LHON against other cohorts using the provided phase-specific slope estimates.

Strengths

• Contains 10 years of continuous follow-up data for 53 eyes from 27 patients, a long observation period for this condition.
• Data includes statistically modeled slopes with confidence intervals for three distinct clinical phases (Acute, Chronic, Late Chronic).
• Kaplan–Meier analyses provide cumulative probability estimates for achieving specific visual acuity milestones.

Limitations

• Modest sample size of 27 patients from a single center in Japan may limit generalizability.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• Selection bias is noted, as the cohort consists of long-term attendees at a tertiary hospital.

Provenance

Source

Single-center retrospective cohort study at a tertiary eye hospital in Japan.

Collection Method

Retrospective data collection from genetically confirmed LHON patients with ≥10 years of continuous follow-up.

Time Range

Data spans from disease onset to 120 months (10 years) per patient.

Freshness

Last updated 2026-04-28 17:26:59; freshness should be verified.

Geography

Japan